2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-105481
    CGS-17867A hydrochloride 102200-24-8 98%
    CGS-17867A (hydrochloride) is a benzodiazepine receptor ligand. CGS-17867A (hydrochloride) has a weak sedative effect and can increase palatable food intake.
    CGS-17867A hydrochloride
  • HY-105485
    FR-62765 105346-34-7 98%
    FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy.
    FR-62765
  • HY-105498
    ADD-196022 142458-16-0 98%
    ADD-196022 is an orally active antiepileptic and anticonvulsant agent. ADD-196022 shows ED50 values of 26.2 mg/kg and 5.79 mg/kg for intraperitoneal injection in mice and orally administration in rats. ADD-196022 can be used for the research of neurological disease.
    ADD-196022
  • HY-105500
    BW-1003C87 Ethylsulfate 144425-86-5 98%
    BW-1003C87 (Ethylsulfate) is a glutamate release inhibitor. BW-1003C87 (Ethylsulfate) exhibit neuroprotective effect. BW-1003C87 (Ethylsulfate) can elevate seizure threshold. BW-1003C87 (Ethylsulfate) can be used for the research of neurological disease, such as ischemic and seizure.
    BW-1003C87 Ethylsulfate
  • HY-105534
    TAK-637 217185-75-6 98%
    TAK-637 is an orally active neurokinin-1 receptor antagonist. TAK-637 increases bladder storage capacity. TAK-637 can be used for research of functional bowel diseases such as irritable bowel syndrome.
    TAK-637
  • HY-105539
    EMD 86006 427889-61-0 98%
    EMD 86006 is a candidate for selective serotonin inhibitors. EMD 86006 has the potential for research on depressive disorders.
    EMD 86006
  • HY-105569
    Amphotalide 1673-06-9 98%
    Amphotalide is an anticonvulsant.
    Amphotalide
  • HY-105604
    Anilopam 53716-46-4 98%
    Anilopam is an opioid analgesic belonging to the benzazepine class and acts as an agonist at opioid receptors.
    Anilopam
  • HY-10560A
    Temanogrel hydrochloride 957466-27-2 98%
    Temanogrel hydrochloride is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.
    Temanogrel hydrochloride
  • HY-105616
    Roflurane 679-90-3 98%
    Roflurane (DA 893) is a halocarbon agent that can relieve pain.
    Roflurane
  • HY-105631
    Hydroxytetracaine 490-98-2 98%
    Hydroxytetracaine is a local agent that can suppress or relieve pain.
    Hydroxytetracaine
  • HY-105652
    Ambucetamide 519-88-0 98%
    Ambucetamide is an antispasmodic agent. Ambucetamide alleviates menstrual pain.
    Ambucetamide
  • HY-105667
    Butanixin 55285-35-3 98%
    Butanixin (2-[(4-Butylphenyl)amino]-3-pyridinecarboxylic acid) is a cyclooxygenase (COX) inhibitor. It exerts anti-inflammatory and analgesic activity by reducing prostaglandin production. It is used in the research of musculoskeletal disorders.
    Butanixin
  • HY-105690
    SAR-115740 1253734-75-6 98%
    SAR-115740 is a TRPV1 antagonist. SAR-115740 exhibits developmental toxicity in H9 cell experiments. SAR-115740 can be used for research on inflammatory conditions or neurological disorders.
    SAR-115740
  • HY-10570S
    Nevirapine-d4 1051418-95-1 98%
    Nevirapine-d4 is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM.
    Nevirapine-d4
  • HY-105738
    Butaverine 55837-14-4 98%
    Butaverine is an antispasmodic compound.
    Butaverine
  • HY-105744
    Leiopyrrole 5633-16-9 98%
    Leiopyrrole (DV-714), a 2-arylated pyrrole derivative, is an anticholinergic agent.
    Leiopyrrole
  • HY-105749
    Pentamethonium bromide 541-20-8 98%
    Pentamethonium bromide is a ganglion blocker that exhibits antihypertensive and vasodilatory activities.
    Pentamethonium bromide
  • HY-105771
    Parapenzolate bromide 5634-41-3 98%
    Parapenzolate bromide, an antispasmodic, is an orally active mAChR antagonist. Parapenzolate bromide is an anticholinergic agent.
    Parapenzolate bromide
  • HY-105785
    Clomacran 5310-55-4 98%
    Clomacran (SKF 14336; SKF 14336D) is a potent antipsychotic agent.
    Clomacran
Cat. No. Product Name / Synonyms Application Reactivity